My Stupid Boss recounts the story of an absurd boss and his employees. Bossman (Reza Rahadian) is an Indonesian who owns a company in Kuala Lumpur. A large but disorganized company. The culprit for the disarray in the organization is the bossman himself. His first principle of management is that Bossman Is Always Right. Which means whatever the Bossman fancies, he'll get it done. And that is his following principle: Impossible We Do Miracle We Try. In the midst of this is Diana, the Bossman's secretary, who has to juggle at every turn with the odds that never seem to add up in the company. Diana's daily confronted with her boss's antics and her patience and good sense are all put to the test.

A group of lucky draw winners win a dream vacation on a seemingly idyllic island resort. Yet, all is not what it seems as people start disappearing... one by one. after the electric fence that has kept the natural habitat and the human visitors apart starts to malfunction. Myra, an entertainment journalist, soon uncovers the reality of them being trapped on an island infested with deadly and hungry pythons. Without access to telecommunications for help, the only way to get off the island is via a passenger boat that is scheduled to arrive in three days.

In the outskirts and back-alleys of Kuala Lumpur, several individuals with money problems struggle to get their lives straight, finding their paths unexpectedly intersecting - with fatal results.